Built on top of the open-source PyLabRobot framework, VERID provides four core capabilities:

• •Live 3D state tracking: Allow agents to check deck layout, well volumes, and available tips before acting.
• •Fast virtual dry runs: Simulate protocols in seconds to catch collisions or empty wells before touching reagents.
• •Hardware safety checks: Block invalid commands before they reach the robot.
• •Synchronized video and action logs: Capture a complete record of every run for research rigor, reproducibility, and debugging.

In our report, we show these capabilities in action through case studies. First, synchronized video and execution traces caught uneven dye stratification caused by dispensing too close to the well floor, allowing the agent to refine its mixing strategy. In the same campaign, the persistent digital twin state allowed the agent to recover mid-run from a plate-reader failure without re-pipetting. Second, when the simulator rejected an 8-channel aspiration that physically wouldn't fit in a narrow trough, the agent replanned on the fly and designed a targeted factorial diagnostic isolating a subtle bias caused by residual tip-wall carryover that replication alone would have missed. Finally, in a closed-loop self-play campaign, an agent iteratively designed and ran robot experiments to reconstruct blinded dye mixtures from overhead camera images, identifying its own optical and fluidic artifacts across runs to improve accuracy more than fivefold.

Reproducible execution and full trace logs — capturing procedural variables like dwell times, evaporation, and plate layout — lay the groundwork for agents to eventually be able to separate biological signals from experimental noise as they explore and refine many candidates in parallel across rounds.