Institute for Health Metrics and Evaluation

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   Lancet report ranks malicious AI use with nuclear conflict as top 2100 extinction risk

   A Lancet Commission report on 21st-century global health threats, released Oct. 11 and written by 35 experts covering 204 countries and regions, lists nuclear conflict and malicious use of AI as the only two of 17 threats that could cause human extinction by 2100 — while stressing that both remain unlikely. It estimates malicious AI use could cost about 10.4 billion disability-adjusted life years (DALYs) by 2100, a scale comparable to obesity, versus roughly 133 million deaths and 9.35 billion DALYs from nuclear conflict, and says AI's main extinction pathway is bioweapons, as large models lower the barrier to designing or modifying pathogens. The debate is split: Anthropic's threat-intelligence report described five cases of Claude misuse that may have supported bioweapon research, its alignment head Evan Hubinger put the chance of AI killing everyone within a decade above 10%, Jensen Huang said 0% by 2030, and Gary Marcus called agent-takeover-of-the-Internet claims absurd.

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