Howard Hughes Medical Institute

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   Eric Betzig Warns AlphaFold Alone Cannot Solve Drug Discovery

   Nobel laureate Eric Betzig argued in a podcast interview that using AlphaFold protein structures alone for drug discovery is unlikely to succeed, because cells are dynamic, crowded, multiscale systems. He proposed combining live-cell 4D/5D imaging, self-supervised vision Transformers and zebrafish models to study drug effects from molecules to whole organs, while also criticizing academic incentives built around papers, grants and peer review.

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